Search results for " Analgesic"

showing 10 items of 38 documents

Low morphine doses in opioid-naive cancer patients with pain

2006

Cancer pain can be managed in most patients through the use of the analgesic ladder proposed by the World Health Organization. Recent studies have proposed to skip the second "rung" of the ladder by using a so-called "strong" opioid for moderate pain. However, usual doses of strong opioids commonly prescribed for the third rung of the analgesic ladder may pose several problems in terms of tolerability in opioid-naive patients. The aim of this multicenter study was to evaluate the efficacy and tolerability of very low doses of morphine in advanced cancer patients no longer responsive to nonopioid analgesics. A sample of 110 consecutive opioid-naive patients with moderate-to-severe pain were …

AdultMalePainWHO method cancer pain opioids morphineOpioidDose-Response RelationshipQuality of lifeNeoplasmsWHO methodMedicineHumansCancer painOpioid peptideGeneral NursingNursing (all)2901 Nursing (miscellaneous)AgedAnalgesicsDose-Response Relationship DrugCancer pain; Morphine; Opioids; WHO method; Adult; Aged; Analgesics Opioid; Dose-Response Relationship Drug; Female; Humans; Male; Middle Aged; Morphine; Neoplasms; Pain; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology (clinical); Neurology; Nursing (all)2901 Nursing (miscellaneous)Morphinebusiness.industryCancerMiddle Agedmedicine.diseaseAnalgesics OpioidClinical trialOpioidsTreatment OutcomeAnesthesiology and Pain MedicineTolerabilityOpioidNeurologyAnesthesiaMorphineFemaleNeurology (clinical)DrugbusinessCancer painmedicine.drug
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Typical trigeminal neuralgia by an atypical compression: case report and review of the literature.

2014

Aim Trigeminal neuralgia is a disabling form of facial pain that causes a considerable discomfort and a marked reduction in the quality of life. Although neurovascular compression is often associated with trigeminal neuralgia, other intracranial pathologies can result in compression along the nerve. Case description The authors report a case of a patient suffering from a typical left trigeminal neuralgia affecting both the second and the third branches. Neuroradiological examinations showed the presence of an arachnoid cyst located in the left temporal lobe, contiguous with the Meckel's cave, eroding the greater wing of the sphenoid bone. Following a meticulous decision-making process the p…

AdultMalemedicine.medical_specialtytypical trigeminal neuralgiaSphenoid bonePainMagnetic resonance angiographyArachnoid cystTrigeminal neuralgiaSphenoid BonemedicineHumansCranial nerve diseaseArachnoid cyst; Conservative treatment; Trigeminal neuralgia; Adult; Analgesics Non-Narcotic; Carbamazepine; Cranial Nerve Diseases; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Nerve Compression Syndromes; Pain; Sphenoid Bone; Treatment Outcome; Trigeminal Neuralgia; Neurology (clinical); SurgeryPathologicalmedicine.diagnostic_testbusiness.industrySettore MED/27 - NeurochirurgiaNerve Compression SyndromesCarbamazepineAnalgesics Non-NarcoticTrigeminal Neuralgiamedicine.diseaseMagnetic Resonance ImagingCranial Nerve Diseasesnervous system diseasesSurgeryNerve compression syndromebody regionsCarbamazepineTreatment OutcomeSurgeryNeurology (clinical)medicine.symptombusinessMagnetic Resonance Angiographymedicine.drug
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Pharmacological management of cancer pain in children

2014

The aim of this review was to assess cancer pain management in children on the basis of research published in the last ten years. Nine were papers providing clinical data, with a minimum of ten patients. No controlled studies were found. Regardless of general principles and existing recommendations, clinical data should confirm the applicability of this concept. The trials published in the last years did not provide further information to improve cancer pain management in children, because of the experience and the low number of drugs used, reflecting only meaningful opinions of experts in the field. The amount and the quality of data still remain poor, as only 737 subjects (about 80 patien…

Analgesicsmedicine.medical_specialtybusiness.industryCancer pain Pediatric painBreakthrough PainPharmacological managementAlternative medicinePainSettore MED/41 - AnestesiologiaHematologyPharmacologyClinical trialOncologyOpioidNeoplasmsHumansMedicineChildbusinessAdverse effectOpioid analgesicsIntensive care medicineCancer painmedicine.drug
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Clinical Problems with Transdermal Fentanyl Titration from 25 to 50 μg/hr

2001

Anesthesiology and Pain Medicinebusiness.industryAnesthesiamedicineTitrationNeurology (clinical)businessOpioid analgesicsGeneral NursingFentanylmedicine.drugTransdermalJournal of Pain and Symptom Management
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Breakthrough pain: On the road again

2009

DrugAnesthesiology and Pain MedicineText miningbusiness.industryBreakthrough Painmedia_common.quotation_subjectMEDLINEMedicineOpioid analgesicsbusinessBioinformaticsmedia_commonEuropean Journal of Pain
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Status of hormones and painkillers in wastewater effluents across several European states-considerations for the EU watch list concerning estradiols …

2016

Present technologies for wastewater treatment do not sufficiently address the increasing pollution situation of receiving water bodies, especially with the growing use of personal care products and pharmaceuticals (PPCP) in the private household and health sector. The relevance of addressing this problem of organic pollutants was taken into account by the Directive 2013/39/EU that introduced (i) the quality evaluation of aquatic compartments, (ii) the polluter pays principle, (iii) the need for innovative and affordable wastewater treatment technologies, and (iv) the identification of pollution causes including a list of principal compounds to be monitored. In addition, a watch list of 10 o…

EngineeringHealth Toxicology and Mutagenesis0208 environmental biotechnologyAdvanced technologiesReview Article02 engineering and technologyWastewater010501 environmental sciencesEthinyl EstradiolWaste Disposal Fluid01 natural sciencesEnvironmental monitoringWater Pollutantsmedia_commonAnalgesicsEstradiolWaste managementEU watch listWaste DisposalGeneral MedicinePollutionWastewaterPollutant removalMilieutechnologieSewage treatmentFluidNanofiltrationEnvironmental MonitoringDiclofenacAdvanced technologies; Diclofenac; EU watch list; Effluent quality; Emerging pollutants; Ethinylestradiol; Pollutant removal; Analgesics; Diclofenac; Environmental Monitoring; Estradiol; Ethinyl Estradiol; European Union; Waste Disposal Fluid; Waste Water; Water Pollutants ChemicalChemicalEmerging pollutantsEthinylestradiolHazardous wasteEnvironmental Chemistrymedia_common.cataloged_instanceWaste WaterEuropean UnionEuropean union0105 earth and related environmental sciencesPollutantWIMEKbusiness.industryAdvanced Technologies ; Diclofenac ; Eu Watch List ; Effluent Quality ; Emerging Pollutants ; Ethinylestradiol ; Pollutant RemovalPolluter pays principle020801 environmental engineeringEffluent qualityEnvironmental TechnologybusinessWater Pollutants Chemical
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The effects of morphine on the temporal structure of Wistar rat behavioral response to pain in hot-plate

2016

Rationale: The largest amount of researches on the hot-plate test was carried out using quantitative assessments. However, the evaluation of the relationships among the different elements that compose the behavioral response to pain requires different approaches. Although previous studies have provided clear information on the behavioral structure of the response, no data are available on its temporal structure. Objectives: The objective of this study was to investigate the temporal structure of the behavioral response to pain in Wistar rat tested in hot-plate and how this structure was influenced by morphine-induced analgesia. Methods: The behavior of four groups of subjects tested in hot-…

Male0301 basic medicineHot TemperatureTime FactorsHot-platemedicine.medical_treatmentPharmacology toxicologyPainPhysiologyWistar ratSettore BIO/09 - Fisiologia03 medical and health sciences0302 clinical medicinemedicineNoxious stimulusAnimalsAnimal behaviorHot plateRats WistarSalinePharmacologyBehavior AnimalMorphineMultivariate analysiT-pattern analysiRatsAnalgesics Opioid030104 developmental biologyBehavioral responseMultivariate AnalysisExploratory BehaviorMorphineOpioid analgesicsPsychologyNeuroscience030217 neurology & neurosurgerymedicine.drugPsychopharmacology
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Pain monitoring and management in a rehabilitation setting after total joint replacement

2018

Abstract Total hip replacement (THR) and, particularly, total knee replacement (TKR), are painful surgical procedures. Effective postoperative pain management leads to a better and earlier functional recovery and prevents chronic pain. Studies on the control of pain during the postoperative rehabilitation period are not common. The aim of this study is to present results of a perioperative anesthetic protocol, and a pain treatment protocol in use in the Orthopaedic and the Rehabilitation intensive units of our Hospital. 100 patients (50 THR and 50 TKR) were retrospectively included in this observational study. Numeric Rating Scale (NRS) for pain at rest registered in the clinical sheet was …

MaleArthroplasty Replacement HipMultimodal analgesic protocolmedicine.medical_treatmentObservational StudyPain03 medical and health sciences0302 clinical medicinemultimodal analgesic protocol pain rehabilitation total joint replacementmedicineHumansPain ManagementTotal joint replacementArthroplasty Replacement KneeTotal joint replacementAgedPain MeasurementRetrospective StudiesAnalgesicsPain Postoperative030222 orthopedicsRehabilitationbusiness.industrySettore MED/34 - Medicina Fisica E RiabilitativaRehabilitationChronic painAnalgesia Patient-ControlledRetrospective cohort studyRecovery of FunctionGeneral MedicinePerioperativeMiddle Agedmedicine.disease6300ArthroplastyhumanitiesTreatment OutcomeAnesthesiaAnestheticFemaleObservational studybusinesshuman activities030217 neurology & neurosurgeryResearch Articlemedicine.drugMedicine
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Does pain intensity predict a poor opioid response in cancer patients?

2011

Abstract Aim The aim of this study was to test the hypothesis that initial pain intensity is not a predictive factor of poor opioid response in advanced cancer patients, as suggested by a recent work. Methods A secondary analysis of one-hundred-sixty-seven patients referred for treatment of cancer-related pain was conducted. Pain intensity at admission was recorded and patients were divided in three categories of pain intensity: mild, moderate and severe. Patients were offered a treatment with opioid dose titration, according to department policy. Data regarding opioid doses and pain intensity were collected after dose titration was completed. Four levels of opioid response were considered:…

MaleCancer ResearchOpioid responseopioid response in cancer patientPainOpioidSettore MED/42 - Igiene Generale E ApplicataSecondary analysisNeoplasmsmedicineHumansProspective StudiesCancer painKarnofsky Performance StatusAdverse effectAgedPain Measurementpain intensityAnalgesicsAnalysis of VarianceAssessment tools; Cancer pain; Opioid response; Aged; Analgesics Opioid; Analysis of Variance; Female; Humans; Karnofsky Performance Status; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Prospective Studies; Treatment Outcome; Cancer Research; Oncologybusiness.industryCancerMiddle Agedmedicine.diseaseAdvanced cancerIntensity (physics)Predictive factorAnalgesics OpioidAssessment toolsTreatment OutcomeOncologyOpioidAnesthesiapain intensity; opioid response in cancer patients; trial clinicoFemaletrial clinicoCancer painbusinessmedicine.drugEuropean journal of cancer (Oxford, England : 1990)
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Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management.

2008

The aim of this study was to compare the analgesic and adverse effects, doses, as well as cost of opioid drugs, supportive drug therapy and other analgesic drugs in patients treated with oral sustained-release morphine, transdermal fentanyl, and oral methadone.One hundred and eight cancer patients, no longer responsive to opioids for moderate pain, were selected to randomly receive initial daily doses of 60 mg of oral sustained-release morphine, 15 mg of oral methadone, or 0.6 mg (25 microg/h) of transdermal fentanyl. Oral morphine was used as breakthrough pain medication during opioid titration. Opioid doses, pain intensity, adverse effects, symptomatic drugs, were recorded at week interva…

MaleCost-Benefit AnalysisAdministration OralFentanylNeoplasmscancer pain opioidsProspective StudiesCancer painTransdermalIntractableAnalgesicsMorphineMiddle AgedPain IntractableAnalgesics OpioidFentanylNeuropsychology and Physiological PsychologyTreatment OutcomeNeurologyPatient SatisfactionAnesthesiaAdministrationFemaleDrugmedicine.drugOralAdultAdolescentAnalgesicPainOpioidAdministration CutaneousDrug Administration ScheduleDose-Response RelationshipmedicineHumansAdverse effectAgedDose-Response Relationship Drugbusiness.industryCostsCutaneousAnesthesiology and Pain MedicineOpioidCancer pain; Costs; Fentanyl; Methadone; Morphine; Administration Cutaneous; Administration Oral; Adolescent; Adult; Aged; Analgesia; Analgesics Opioid; Cost-Benefit Analysis; Dose-Response Relationship Drug; Drug Administration Schedule; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain Intractable; Patient Satisfaction; Prospective Studies; Quality of Life; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology; Neuropsychology and Physiological PsychologyMorphineQuality of LifeAnalgesiaCancer painbusinessMethadoneMethadoneEuropean journal of pain (London, England)
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